Gene Drives' Mathematical Modeling


John Marshall's Lab.
Héctor M. Sánchez C.
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Agenda

I. General Picture
II. Threshold-Dependent Systems
III. Other Work & Future Directions


I. General Picture


1) MGDrivE: Gene Drive Simulations
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Valeri Vasquez

2) Fitting Drives to Lab Data
Jared B. Bennett, Omar S. Akbari, Ethan Bier, Anthony James


3) Fitting Mosquito Movement from Field Data
Tomás León, Gordana Rašić, Yogita Sharma, Sanjay Lamba


4) MGDrivE + MoNeT: Genetic Landscape Analysis
Héctor M. Sánchez C., Víctor Ferman*, Gillian Chu, Maya Shen, Yunwen Ji, Sarafina Smith*, Biyonka Liang*




II. Threshold-Dependent Systems


1) Geographic Setting
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari



2) Gene-Drives
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari


3) Simulated Releases
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari


4) Fixation Thresholds
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari



4) Fixation Thresholds
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari



5) Remediation Potential
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari



6) Fixation/Remediation Summary
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari

7) Batch Migration
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari


7) Batch Migration
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari



7) Batch Migration Summary
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari


8) Conclusion
Héctor M. Sánchez C., Jared B. Bennett, Sean L. Wu, Gordana Rašić, Omar S. Akbari



III. Other Work & Future Directions


1) Landscapes Aggregation and Heterogeneity
Gillian Chu, Yunwen Ji, Maya Shen, Biyonka Liang*, Victor Ferman*, Sean Wu, Héctor M. Sánchez C.
2) Anopheles Mosquito Movement Kernels
Tomás León


3) MGDrivE v2.0
Sean L. Wu, Jared B. Bennett, Héctor M. Sánchez C.

4) Genetic Inference of Mosquito Movement
Gordana Rašić, Yogita Sharma, Sanjay Lamba

Team and Questions

John Marshall's Lab





Postdoc/Research Associates: Héctor M. Sánchez C., Tomás León, Gordana Rašić, Yogita Sharma, Victor Ferman*, Sanjay Lamba

PhD Students: Jared Bennett, Sean L. Wu, Valeri Vasquez

Masters Students: Thien-An Ha

Undergraduate Students: Gillian Chu, Maya Shen, Yunwen Ji, Biyonka Liang*, Sarafina Smith*, Sabrina Wong*

* Former lab members